Efficacy analysis of percutaneous microwave ablation in treatment of hepatic metastases from gastric adenocarcinoma after gastrectomy

Abstract

Objective To evaluate the efficacy of of percutaneous microwave ablation(MWA) in treatment of hepatic metastases from gastric adenocarcinoma after gastrectomy. Methods Twenty- four patients who underwent percutaneous MWA after gastrectomy for a hepatic metastasis from a gastric cancer from October 2009 to October 2014. Median age was (63 ± 11) years. Three-two times MWA was done in 27 metastatic tumors. Patients′ outcomes were assessed by enhancement CT or MRI. Results The rate of total ablation was 92.6% (25/27). The deadline of follow up was 2016 - 04 - 01. One patient was living and 23 patients died with tumor progression. The median overall survival was 24.1(95% CI: 9.8 -34.3) months. The survival rate of 1, 2, 3, 4 and 5 years was 78.7%, 40.7%, 38.5%, 19.4% and 8.2%. The median progression-free survival was 13.4 (95% CI: 2.0 - 30.4) months, and the survival rate of local progression-free of 6 months, 1, 2 and 3 years was 64.3%, 50.1%, 40.2% and 26.9%. The main complication was moderate and severe pain in 10 cases, and 17 cases had post ablation syndrome. Conclusions For patients with metastatic tumors ≤ 3 cm, MWA is a safe and feasible treatment option for hepatic metastases from gastric adenocarcinoma. Key words: Stomach neoplasms; Neoplasm metastasis; Microwave ablation