Efficacy Analysis of Levofloxacin Combined with Cefoperazone/Sulbactam Sodium in the Treatment of Adult Bronchiectasis Complicated with Infection

Abstract

Objective: To investigate the efficacy of levofloxacin combined with cefoperazone/ sulbactam sodium in the treatment of bronchiectasis complicated with infection in adults and its effect on lung function. Methods About 200 patients with bronchiectasis and infection from May 2019 to July 2022 in Jintan First People's Hospital of Changzhou City, Jiangsu Province were selected and divided into 2 groups (100 cases in each group) according to the treatment plan. The control group received cefoperazone /sulbactam sodium treatment, the observation group was treated with levofloxacin on the basis of the above. The evaluation was conducted by comparing the time of improvement of clinical symptoms, the decrease of inflammatory indicators, and the improvement of lung function indicators. Results After treatment, the overall effectiveness rate of the observation group was 93%, and the control group was 78%, which was significantly different (P<0.05), cough and sputum production, body temperature recovery and hemoptysis stop time were all earlier than those in the control group (P<0.05). Prior to treatment, there was no significant difference in neutrophil values (GRAN), white blood cell count (WBC), and hypersensitive C-reactive protein (CRP) between the two groups (P>0.05). After treatment, the GRAN, WBC and CRP of the control group were significantly higher than those in the observation group (P<0.05); there was no significant difference in forced expiratory volume (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC between the two groups before treatment (P>0.05), After treatment, the FVC, FEV1, FEV1/FVC values in the observation group were significantly higher than those in the control group (P<0.05). Conclusion The application of levofloxacin combined with cefoperazone/sulbactam sodium can effectively improve the clinical symptoms, inflammation level and pulmonary function indexes of adult bronchiectasis complicated with infection.