Abstract
BackgroundThe efficacy, acceptability and tolerability of the new oral phosphate binder Lenziaren® (SBR759) were evaluated in a randomized parallel-group design study in 36 healthy cats (n = 6 per group). Five groups were fed once daily with a commercial diet containing 0.2% phosphorus (“standard diet”) into which was mixed Lenziaren® at 0.25, 0.5, 1.0 or 2.0 g/day or no treatment (control group) daily for 30 days. A sixth group was fed a commercial diet containing lower amounts (0.12%) of phosphorus (“renal diet”) and no treatment.ResultsWhen compared to the control group, Lenziaren® produced significant dose-related reductions in urine phosphate concentrations, urine phosphate excretion and fractional urinary phosphate excretion. Significant effects versus the control group were observed at the 0.5, 1.0 and 2.0 g/day dosages. Lenziaren® was well tolerated and was associated with higher food consumption and serum iron concentrations versus the control.When compared to the control group, the renal diet was associated with significantly lower urine phosphate concentrations and loss of body weight. Lenziaren® had similar effects on urine phosphate concentrations compared to the renal diet, but was not associated with loss of body weight.ConclusionsLenziaren® was effective as an oral phosphate binder in cats fed with a standard diet containing 0.2% phosphorus. The acceptability and tolerability were good. Dosages of 0.5-1.0 g/cat per day are recommended for clinical testing in cats fed with a standard diet.
Highlights
The efficacy, acceptability and tolerability of the new oral phosphate binder Lenziaren® (SBR759) were evaluated in a randomized parallel-group design study in 36 healthy cats (n = 6 per group)
In healthy cats fed with a renal diet, Lenziaren® was effective in reducing plasma and urine phosphate concentrations over the dose range 0.25-1.0 g/cat per day and had good acceptability and tolerability [15]
The results demonstrate that Lenziaren® effectively bound phosphate present in the diet, as evidenced by the significantly lower urine phosphate concentrations, urine phosphorus excretion and fractional urinary phosphate excretion
Summary
The efficacy, acceptability and tolerability of the new oral phosphate binder Lenziaren® (SBR759) were evaluated in a randomized parallel-group design study in 36 healthy cats (n = 6 per group). Five groups were fed once daily with a commercial diet containing 0.2% phosphorus (“standard diet”) into which was mixed Lenziaren® at 0.25, 0.5, 1.0 or 2.0 g/day or no treatment (control group) daily for 30 days. Restriction of oral intake of phosphate in cats is achieved most commonly via the feeding of diets containing low. None of the available phosphate binders are ideal for use in cats due to low palatability and/or safety issues related to the oral absorption of aluminium, calcium or lanthanum. In healthy cats fed with a renal diet, Lenziaren® was effective in reducing plasma and urine phosphate concentrations over the dose range 0.25-1.0 g/cat per day and had good acceptability and tolerability [15]. The efficacy and tolerability of Lenziaren® in cats with CKD and hyperphosphataemia and safety in healthy cats have been reported as abstracts [16,17]
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