Efficacies of two medicinal plants [Goma Guar Walmart (Cyamopsis tetragonolobus L.) and Cinnamon (Cinnamomum verum)] versus efficacy of allopathic treatment [Sil–Norboral (Glibenclamide 5 mg/Metformin 1000 mg + Janumet (Sitagliptin 50 mg/Metformin 850 mg)

Abstract

The objective of this study was to statistically compare –using the One–Way Analysis of Variance and Dunnett's multiple comparisons test– the efficacy of Cyamopsis tetragonolobus L. and Cinnamomum verum versus the efficacy of the allopathic treatment Sil–Norboral (Glibenclamide 5 mg/Metformin 1000 mg) + Janumet (Sitagliptin 50 mg/Metformin 850 mg) as hypoglycemic agents in patients with type 2 diabetes mellitus who attend the "Dr. Agustin O'Horán" General Hospital for medical care. The epistemological approach is quantitative, probabilistic or positivistic. The study design corresponds to that of a therapeutic experimental epidemiological study (therapeutic clinical trial) with prospective temporality. Forty–eight patients with type 2 diabetes mellitus were studied. The 48 patients were randomly assigned to three groups: two experimental groups and one control group. Each group was made up of 16 patients. The first experimental group was given Cyamopsis tetragonolobus L. (twelve dry leaves of Cyamopsis tetragonolobus L. and 500 ml of hot water); pour the 500 ml of hot water into a container and add the twelve dry leaves of Cyamopsis tetragonolobus L.; take 250 ml in the morning and 250 ml at night); the second experimental group was given Cinnamomum verum (two g of dry leaves of Cinnamomum verum and 500 ml of hot water; pour the 500 ml of hot water into a container and add two g of dry leaves of Cinnamomum verum; take 250 ml in the morning and 250 ml at night); and the control group was given the Sil–Norboral allopathic treatment (Glibenclamide 5 mg/Metformin 1000 mg) + Janumet (Sitagliptin 50 mg/Metformin 850 mg). In ascending numerical order, the arithmetic means of the hematic glucose values ​​corresponded to the following treatments: Cyamopsis tetragonolobus L. (84.06 mg/100mL); Cinnamomum verum (88.63mg/100mL); and Sil–Norboral (Glibenclamide 5 mg/Metformin 1000 mg) + Janumet (Sitagliptin 50 mg/Metformin 850 mg) (122.25 mg/100mL). The One–Way Analysis of Variance reported a value of F= 56.03 with a value of p= 0.0000, which indicates a statistically significant difference between a pair or between more than one pair of arithmetic means. Dunnett's multiple comparisons test showed statistically significant differences between the treatment with the medicinal plant Cyamopsis tetragonolobus L. and the allopathic treatment Sil–Norboral + Janumet: p= 0000. Likewise, Dunnett's multiple comparisons test showed a statistically significant difference between the treatment with the medicinal plant Cinnamomum verum and the allopathic treatment Sil–Norboral + Janumet: p= 0.0000. It is concluded that Cyamopsis tetragonolobus L. is, from a numerical and not a statistical point of view, the best hypoglycemic agent for the treatment of type 2 diabetes mellitus.