Abstract
AimTo evaluate the therapeutic effects of dietary krill oil supplementation in modulation of oxidative stress components and DNA oxidative damages marker in cafeteria diet-overfed-rats. Material and methodsEighteen aging male Wistar rats were divided into three groups of six each and were exposed for the ensuing 8 weeks to one of the diets: control group (TS) which was submitted to standard chow (330kcal/100g), containing 24% of proteins, 5% of lipids and 70% of carbohydrates. Cafeteria standard group (TC) exposed to cafeteria diet (420kcal/100g). The last group received a cafeteria diet enriched in oral force-feeding krill oil 2% (CK). The plasma and tissues pro-oxydant status were assessed by assaying thiobarbituric acid reactive substances, hydroperoxydes, and isoprostans. The determination of DNA oxidative damages was evaluated by the measurement of the major products of DNA oxidation (8-OHdG). ResultsExposure to a cafeteria diet increases the metabolic response to the radical attack and DNA oxidative damages in both plasma and key tissues involved in antioxidant defense. Krill oil supplementation in cafeteria diet relieves oxidative stress and DNA damages by lowering several lipid peroxidation components and the main marker of DNA oxidation in obese rats.
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