Abstract
The lindane or hexachlorocyclohexane γ isomer inhibited cell division in two cultivated unicellular algae and caused morphological changes of enlarged cells; increase of the golgi apparatus, endomultiplication of the organelles, abnormal partition of nuclei, and a decrease in the number of microtubules were observed. However, lindane did not change the polymerization of tubulin in vitro. In synchronously dividing Dunaliella bioculata, mitosis could be blocked even if the insecticide was added to cultures after the beginning of the outburst of cell division during the dark period. During the first cell cycle, the RNA and protein cell content increased more slowly in treated cells and then continued to increase more or less rapidly during the second cell cycle. The DNA synthesis was strongly inhibited by 10 μg/mL of lindane and depressed by 5 μg/mL as early as the first cell cycle. The synthesis did not resume during the second cell cycle.
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