Abstract
Zearalenone, a macrocyclic lactone, shows a limited antibacterial activity which can be demonstrated in Grampositive spore-forming bacteria. In a sensitive Bacillus thuringiensis (Berliner), the mycotoxin disturbs various bacterial metabolisms: physiological damages (decreased growth rate, inhibition of sporulation and enzyme synthesis) and cellular alterations (filamentous forms or snake-cells) are noted. On the other hand, although zearalenone has been found to give a positive response in the presumptive screening test for mutagens measured by DNA-attacking ability on Bacillus subtilis, this mycotoxin failed to demonstrate mutagenicity in routine test using liver homogenate and Salmonella typhimurium strains.
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