Effets de la restriction alimentaire appliquée à des rates adultes sur la croissance osseuse et la structure histologique de la thyroïde chez leurs jeunes

Abstract

Study purposeOur objective was the study of the development and the maturation of pups whose mothers were subjected to intermittent fasting. Materials and methodsEight pregnant female Wistar rats were distributed into two groups of four adult females. The rats of the first group were subjected to intermittent fasting beginning on the 14th day of gestation and continued 21 days after parturition. The rats of the second group were normally fed. The young of both groups of rats were sacrificed at the age of 21 days. ResultsThe pups of the female rats submitted to food restriction showed a reduction of the body weight (–35%), of the thyroid iodine content (P<0.001) and of segment thyroxin (P<0.05). The histological study revealed that these pups presented colloid depletion of this follicular thyroid, non-anastomosing trabeculae, cortical bone thinning, decreased bone mineral content, absence of osteoid formation and decreased number of osteoclasts. ConclusionDietary restriction imposed on adult rats, from gestation, led to the installation in their pups of a state of malnutrition and a description of thyroid histology. This thyroid abnormality is associated with hypothyroidism that led, at least in part, to the collapse of the ability to regulate bone remodeling.