Abstract
The discovery of a gonad-stimulating or gonadotropic hormone in human urine in certain cases of menopause and castrate women has further complicated the endocrine picture of the reproductive process. This principle appears to be gonadotropic and, in laboratory animals, has stimulated germ cell division. The most striking results with castrate and menopausal urine extracts have been obtained in the male monkey and consisted of stimulation of spermatogenesis (1, 2, 3). With this in mind, we investigated the effects of these extracts on spermatogenesis in human adults. So far as we know, no survey of the influence of this extract on humans has been reported. This castrate and menopausal urine extract can be described as a polypeptid-like substance, which apparently is either identical with, or very similar to the gonadotropic hormone from the anterior lobe itself. It is prepared from the urine of certain castrates and post-menopausal women and is standardized by the production of large numbers of follicles i...
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