Abstract
Drug regimes designed to preferentially prevent reserpine-induced depletion of elther catecholamines or 5-hydroxytryptamine (5-HT) in the brain were used to study shock-elicited aggression in mice. With a drug schedule known to maintain dopamine (DA) and noradrenaline (NA) at normal levels but producing a reduction in brain 5-HT, mice displayed an increase in fighting but no change in either locomotor activity or shock threshold. Animals treated with either reserpine or with a drug regimen producing normal levels of 5-HT but reduced DA and NA showed a decrease in aggression and motility but slightly elevated shock thresholds. In view of the motor impairment observed with the latter two regimens, it is suggested that, whereas catecholamines may play an important role in mediating the motor components of aggressive behavior, 5-HT may significantly contribute to the modulation of mood-dependent aspects.
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