Effects on reduction adverse reactions rates of peripheral blood stem cell collection by measures of comprehensive interventions and nursing cares

Abstract

Objective To study the effects of comprehensive interventions and nursing measures on reducing the adverse reactions rates of collecting peripheral blood stem cell (PBSC). Methods From January 2013 to May 2016, a total of 160 patients who received autologous PBSC collection in Department of Hematology, West China Hospital, Sichuan University were chosen as study subjects. According to their odd and even numbers of admission orders, they were randomly divided into research group and control group, and 80 patients in each group. For research group, real-time and specific comprehensive interventions and nursing cares were performed in addition to regular nursing measures before, during and after autologous PBSC collecting. For control group, in contrast, only regular nursing measures were performed before, during and after autologous PBSC collecting. The general clinical informations and adverse reactions (including anxiety/fear, insomnia, anorexia, hypocalcemia, insufficient blood flow, puncture site hematoma and physical exhaustion) rates in two groups were recorded and compared by statistical methods. The procedures followed in this study were in line with the ethical standards promulgated by the Ethical Review Board of Investigation in Human Being of West China Hospital, Sichuan University. Informed consent was obtained from each participating patient. Results There were no significant differences between two groups in composition ratio of gender, course of disease, disease type, and age, body mass index, and so on (P>0.05). The adverse reactions rates in research group among anxiety/fear, insomnia, anorexia, hypocalcemia, insufficient blood flow, and puncture site hematoma all were distinguished lower than those in control group, and all the differences were statistically significant (χ2=13.333, P 0.05). Conclusions Combination of comprehensive intervention and nursing measures can significantly improve the psychological state of autologous PBSC collection patients and reduce the adverse reactions rates of anxiety/fear, insomnia, anorexia, hypocalcemia, insufficient blood flow, and puncture site hematoma, except of physical exhaustion. Key words: Hematopoietic stem cells; Collection; Adverse reaction; Comprehensive intervention; Nursing care