Abstract
Abstract Coprine, the disulfiram‐like constituent of the mushroom Coprinus atramentarius was found to inhibit the low‐Km acetaldehyde dehydrogenase in rat liver and to increase the acetaldehyde level in blood during ethanol metabolism in vivo. Coprine did not inhibit the low‐Km enzyme in vitro, but the hydrolytic product of coprine, 1 ‐aminocyclo‐propanol, was a potent inhibitor both in vitro and in vivo. A rapid onset of inhibition was observed after administration of coprine and the inhibition was long‐lasting. It is suggested that 1‐aminocyclo‐propanol is responsible for the inhibition caused by coprine in vivo.
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