Abstract
The effects of N-oxidation on the 15N chemical shifts of the Strychnos alkaloids strychnine and brucine are discussed. The 15N shifts were determined using the inverse-detected, long-range GHMBC experiment at natural abundance. Following N-oxidation, the N-19 resonance shifted downfield from 35.0 ppm in strychnine to 136.3 ppm in the N-19-oxide. The N-19 resonance of brucine shifted downfield from 35.9 to 135.5 ppm in the N-19-oxide. Small upfield shifts were observed for the N-9 resonances of both N-oxides. The 1H and 13C shifts of both N-oxides were assigned using inverse-detected 2D NMR methods to ensure proper assignments of the long-range 1H– 15N couplings. Copyright © 1999 John Wiley & Sons, Ltd.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
