Effects ofin UteroAlcohol Exposure on B Cell Development in Neonatal Spleen and Bone Marrow

Abstract

The effects ofin uteroalcohol exposure on neonatal lymphopoiesis were examined in a murine model of fetal alcohol syndrome. At birth, both immature and mature B cells were decreased in the spleens of neonatal animals and these subpopulations of B cells did not recover to normal levels until 3–4 weeks of life. Pre-B cells and total B cells were decreased as well in the bone marrow of ethanol-exposed animals. By 3–4 weeks of life, the number of B cells in the bone marrow recovered to normal levels, but the pre-B cells remained below normal levels through 5 weeks of age. Furthermore, a recently described early B cell progenitor was reduced in frequency in ethanol-exposed neonates. Together, these data suggest thatin uteroexposure to ethanol can result in abnormalities in B cell development that may initiate at an early stage of B cell development.