Abstract
Background: Zinc is an essential micronutrient for human beings and its deficiency affects their normal growth and development. Objective: The main aim was to evaluate the effect of two doses of zinc supplementation (ZS) on the nutritional status in chronic kidney disease (CKD) children. Methods: A randomized-trial multicentric study was conducted in 48 CKD (23 females) patients under 18-years-old, for a year. At random, participants took 30 or 15 mg/day of ZS, respectively. Anthropometric measurements and biochemical analysis were performed. Hypozincemia was determined by serum zinc concentration (SZC) using atomic absorption spectrophotometry. The positive or negative change in patients’ body mass index (BMI) Z-score, serum albumin, zinc and C-reactive protein (CRP) levels were used to evaluate the effect of ZS. Results: Mean SZC was normal before and after ZS. Despite ZS, there were no significant changes in serum albumin, zinc and CRP levels. A positive and significant association was observed between SZC and serum albumin before (p = 0.000) and after (p = 0.007) ZS. In both groups of ZS, there was a small but positive and significant change in body mass and normalization in BMI Z-score, hypoalbuminemia, hypozincemia and high CRP, especially with 30 mg/day of ZS. Conclusions: Zinc supplementation may be beneficial for nutritional status in children and adolescents with CKD.
Highlights
Over the last 10 years [1], chronic kidney disease (CKD) known as chronic renal failure (CRF) is increasingly recognized as a global public health concern and an important contributor to morbidity and mortality [2]
Even though it is more common in adults than in children, CKD is a chronic disease with severe long-term consequences
The proportion and characteristics of the participants at the start did not differ between the study groups (Table 1)
Summary
Over the last 10 years [1], chronic kidney disease (CKD) known as chronic renal failure (CRF) is increasingly recognized as a global public health concern and an important contributor to morbidity and mortality [2]. Nutrients 2019, 11, 2671 countries, increasing evidence indicates that the CKD burden may be even greater in developing countries [3]. The incidence and prevalence of CKD adults is increasing rapidly due to the rapid increase in the prevalence of risk factors such as diabetes, hypertension and obesity [2], which, in the future, will produce a greater burden of CKD [1]. Even though it is more common in adults than in children, CKD is a chronic disease with severe long-term consequences. The positive or negative change in patients’ body mass index (BMI)
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