Abstract
The effect of 0.001–5 mm Zn++ on the contractions of dog, rabbit, and monkey papillary muscles, rat atria, isolated rat hearts, and toad and tortoise ventricular muscle was investigated. Zn++ depressed the contractions of all cardiac muscle preparations tested; the negative inotropic response was associated with an unchanged duration of contraction and a prolonged action potential. Zn++ > 0.5 mm caused mechanical arrest; perfusion of Zn++-arrested amphibian preparations with 100 mm K+ solution resulted in contractures equal in magnitude to that evoked by similar perfusion with 100 mm K+ in the absence of Zn++. It is concluded that the action of Zn++ on cardiac muscle differs essentially from that described for skeletal muscle.
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