Abstract
The effects of Chinese herbs for Zibu Piyin Recipe (ZBPYR) on spleen-Yin deficiency Alzheimer's Disease (AD) rats were investigated. A new rat model was established based on both AD and the spleen-Yin deficiency syndrome. Then, expressions of glucose- regulated protein78 (GRP78), CCAAT/EBP homologous protein (CHOP) in the hippocampus (CA1, CA3, and DAG regions) and cerebral cortex that were correlated to endoplasmic reticulum stress were determined. The results showed that in contrast to the Spleen-Yin Deficiency AD groups, the expression of the GRP78 protein was obviously upregulated (P < 0.05) in the ZBPYR group; whereas the expression of the CHOP protein was obviously downregulated (P < 0.05). It is concluded that Chinese herbs for ZBPYR improve the ability of learning and memory by reinforcing the survival pathway of ERS, and inhibiting the apoptosis pathway of ERS.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
