Abstract
SummaryThe increased excitability (measured as a change in amplitude of monophasic sub-maximal action potentials in a humid chamber) of the isolated sciatic nerve of frog to electrical stimulation after a radiation dose of 10 krads of 50 kV x-rays has been found to be independent of the oxygen content of the atmosphere surrounding the nerve. Increasing the carbon dioxide content of the atmosphere has been found to give an ‘apparent’ increase in the radiation response. However, this increase is due to a radiation reversal of the neural membrane hyperpolarization induced by the carbon dioxide. Increasing the hydrogen ion concentration of the extracellular fluid has been found to reduce the radiation response, whereas radiation enhances the blocking action on the nerve action potential of low concentrations of cocaine. It is postulated that the results of the combined effects of radiation and each of the membrane stabilizers carbon dioxide and cocaine are due to a transient increase of intra-membrane pH indu...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International journal of radiation biology and related studies in physics, chemistry, and medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.