Abstract
Cottonmouth moccasin venom with its necrotizing toxin inactivated 50 to 75 per cent by X-irradiation was studied to determine the alteration of its antigenic character. Immune globulin of rabbits immunized with both normal and X-irradiated venom were compared. The globulin of rabbits immunized with X-irradiated venom showed little difference in its neutralizing titer from the globulin of rabbits immunized with normal venom. A group of animals immunized with normal venom suffered 20 per cent mortality, sloughing of tissue, and severe local reactions around the area of injection. The group of rabbits immunized with X-irradiated venom suffered no mortality or sloughing of tissue. Local reactions around the site of injection were less severe.
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