Abstract

In Experiment 1, six, food-deprived rats were allowed to establish schedule-induced polydipsia on a fixed-time 1-min food schedule. Intragastric preloads of 5 ml of water did not suppress the amount of water consumed during the sessions. Experiments 2 and 3, found that 10 ml intraperitoneal preloads of water or saline also did not suppress schedule-induced polydipsia. These findings indicate that schedule-induced polydipsia is regulated by nonhomeostatic mechanisms, rather than by osmotic or hypovolemic thirst mechanisms. It is suggested that schedule-induced polydipsia is regulated via some oropharyngeal mechanism.

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