Abstract
Fragrances can relax us and bring a good spirit for us. But they cannot produce these results or produce the opposite results if the concentrations of fragrances in the air are large due to their strong volatility. To overcome this obstacle, mesoporous silica nanospheres with the ability of photo-activated releasing sandela 803 (MS-S@S803) were prepared. And the effects and internal mechanism of MS-S-W@S803 on CNS were study from behavioural level, tissue level, cell level and molecule level. MS-S-W@S803 could relieve the stress and beat the anxiety. Besides, it could also stimulate the neural activity of hippocampus, hypothalamus and olfactory bulb regions at a higher intensity. In addition, the abilities of nerve regenerations in corpus striatum, substantia nigra and olfactory bulb were increased by MS-S-W@S803. And the expressions of DOPA, Ach, GABA and NMDA were also facilitated by MS-S-W@S803. Interestingly, the anxiolytic effects were more significant as time progresses.
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