Abstract
Doxorubicin (DOX), a widely used chemotherapeutic agent, manifests toxic side effects in healthy skeletal muscle cells. Existing studies describe attenuation of these myotoxic effects of DOX following exercise preconditioning regimens, but the effects of exercise during and following DOX treatment on myotoxicity are unidentified. Therefore, the objective of this study was to explore the effects of exercise during and following DOX treatment on skeletal muscle function. Male Sprague‐Dawley rats were randomly assigned to the exercise (voluntary wheel running) or sedentary (normal cages) condition for 10 weeks. Throughout this time, animals received DOX (2 mg/kg) or saline once a week for 6 weeks and continued the exercise or sedentary conditions for an additional 4 weeks. Soleus and extensor digitorum longus function was then measured ex vivo. Although DOX treatment impaired muscle function, voluntary wheel running during and following treatment mitigated this effect.
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