Abstract
Background: Atherosclerosis is one of the prevalent complications in diabetic patients. Increased free radical levels in diabetes activate stress-sensitive signaling pathway, resulting in this outcome. This study examines the effect of short-term supplementation of vitamin E on different biochemical markers in type 2 diabetic patients to prevent from atherosclerosis. Materials and Methods: In this single-blind placebo controlled trial, 30 type 2 diabetic patients were randomly divided into two groups of study to receive vitamin E (400IU) or identical placebo capsules daily for 6 weeks. Serum level of lipoproteins, glucose, insulin, malondialdehyde (MDA), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs CRP), pulse rate and blood pressure were measured in fasting and postprandial (after a fatty meal) states before and after six weeks of supplementation. Results: There was not any significant difference in fasting and postprandial lipid profile (Triglyceride, HDL-, LDL- and total Cholesterol), glucose, insulin and HOMA-IR after six weeks of intervention between the two groups. However, results of our study showed a significant decrease in fasting and postprandial MDA levels and postprandial pulse rate and a significant increase in fasting IL-6 in vitamin E group compared to the controls after supplementation. There were no significant differences between the groups in other markers. Conclusion: This study suggests that short term supplementation of vitamin E can reduce oxidative stress in fasting and postprandial states in type 2 diabetic patients and may prevent diabetic complications; in addition, increment of IL-6 after supplementation may play a role in attenuating Type 2 diabetes by anti-inflammatory effects.[GMJ. 2015;4(3):67-74]
Highlights
Type 2 diabetes is an established risk factor for atherosclerosis
Results of our study showed a significant decrease in fasting and postprandial MDA levels and postprandial pulse rate and a significant increase in fasting IL-6 in vitamin E group compared to the controls after supplementation
There were no significant differences between the groups in other markers.Conclusion: This study suggests that short term supplementation of vitamin E can reduce oxidative stress in fasting and postprandial states in type 2 diabetic patients and may prevent diabetic complications; in addition, increment of IL-6 after supplementation may play a role in attenuating Type 2 diabetes by anti-inflammatory effects.[GMJ. 2015;4(3):67-74]
Summary
Type 2 diabetes is an established risk factor for atherosclerosis. Different complications of diabetes such as hyperlipidemia, hypertention, hyperglycemia, inflammation and disturbed endothelial function are involved in initiation of and progression to atherosclerosis [1,2,3]. Different studies have demonstrated decreased serum concentrations of α-tocopherol and ascorbate against increased levels of free radicals in diabetic patients; these are contributing factors for oxidative stress [5]. The aim of this study is to evaluate the effects of vitamin E supplementation on different markers such as blood glucose, insulin, lipid profile, Malondialdehyde (MDA) as lipid peroxidation marker, inflammatory markers, pulse rate and blood pressure in fasting and postprandial states in diabetic patients to show that whether this supplementation can have beneficial effects on modulating underlying risk factors in order to decrease or prevent cardiovascular disease in this group. There were no significant differences between the groups in other markers.Conclusion: This study suggests that short term supplementation of vitamin E can reduce oxidative stress in fasting and postprandial states in type 2 diabetic patients and may prevent diabetic complications; in addition, increment of IL-6 after supplementation may play a role in attenuating Type 2 diabetes by anti-inflammatory effects.[GMJ. There were no significant differences between the groups in other markers.Conclusion: This study suggests that short term supplementation of vitamin E can reduce oxidative stress in fasting and postprandial states in type 2 diabetic patients and may prevent diabetic complications; in addition, increment of IL-6 after supplementation may play a role in attenuating Type 2 diabetes by anti-inflammatory effects.[GMJ. 2015;4(3):67-74]
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