Abstract
A study was conducted to investigate the effects of vitamin C and vitamin E on plasma levels of lipid hydroperoxides (LPO) and thio-barbituric acid reactive substance (TBARS) in human volunteers to identify the step in the lipid peroxidation cascade at which these vitamins act. Forty subjects (20 men and 20 women) were randomly assigned to receive either vitamin C or vitamin E. Twenty subjects received 500 mg of vitamin C daily for 4 weeks, and 20 subjects received 300 mg of vitamin E daily for 4 weeks. Blood samples were collected before and 4 weeks after vitamin treatment, in the morning, after the subjects had fasted for 12 hours. Plasma levels of LPO and TBARS were determined. Plasma levels of lipids, apolipoproteins, vitamin C, and vitamin E were also measured. Vitamin C significantly reduced plasma levels of LPO and TBARS. Vitamin E significantly increased plasma levels of LPO and significantly reduced plasma levels of TBARS. Plasma concentrations of vitamin C and vitamin E significantly increased after 4 weeks of vitamin treatment. There were no significant changes in the plasma levels of lipids except LPO, TBARS, and apolipoproteins. From these results, it was concluded that vitamin C reduced LPO and TBARS levels, and vitamin E increased LPO levels and reduced TBARS levels.
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