Abstract
Muscle, liver, brain, and plasma pyridoxal 5′-phosphate (PLP) concentrations and muscle, liver, and brain glycogen phosphorylase (GPase) activity were determined during vitamin B-6 deficiency and aging. Fischer 344, male rats, aged 15 weeks, and 6, 15, and 25.5 months at the end of the 12-week study, were divided into diet groups of ad libitum controls, deficienct or pair-fed controls. Plasma PLP levels in 25.5-month-old control rats were lower ( P ≤ 0.05) than the other three age groups which were slightly, but not significantly different from each other. Plasma PLP of deficient rats was dramatically decreased ( P ≤ 0.05) in all age groups. Muscle PLP was decreased ( P ≤ 0.05) in all vitamin B-6 deficient rats. Liver and brain PLP concentrations were decreased ( P ≤ 0.05) in 15 week, 6 month, and 15 month deficient rats only. Tissue PLP levels were correlated ( P ≤ 0.01) with plasma PLP. Vitamin B-6 deficiency resulted in decreased glycogen phosphorylase activity ( P ≤ 0.05) in muscle, liver, and brain of 15 week rats, and in muscle and liver of 6 month rats. Reduction in food intake did not account for the reported changes during vitamin B-6 deficiency. A significant correlation between tissue glycogen phosphorylase activity and tissue PLP levels was observed. Vitamin B-6 deficiency significantly lowered tissue PLP and phosphorylase activity, but the decrease in each was less marked with increasing age.
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