Abstract
Vasoactive intestinal polypeptide (VIP) has been shown to exert a hyperglycemic effect in vivo and to induce glucogenolysis in rabbit liver slices [l] but the biochemical evidence supporting an effect of VIP on glucose metabolism in liver cells is scarce [2-31 except for a recently described effect [4]. This effect is thought to be cyclic adenosine monophosphate (CAMP)-dependent since numerous studies have shown that VIP can stimulate rat liver adenylate cyclase through the interaction with a specific membrane receptor [5-81. VIP seems to share this membrane binding site with secretin but not with glucagon [6] or gastric inhibitory polypeptide (GIP) 131. Although the VIP effect on membrane adenylate cyclase was clearly documented, the action of VIP on CAMP levels in isolated liver cells is still unclear [4,8]. The aim of this study was to systematically investigate the actions and mechanism of action of VIP, secretin and GIP, three glucagon-related polypeptides [9], on glucose and lactate metabolism in isolated rat liver cells and to compare them to the known, CAMP-mediated, effects of glucagon.
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