Abstract
We investigated the effects of age and (±)-methyl-3-ethyl-2,3,3 a,4-tetrahydro-1 H-indolo[3,2,1- de][1,5]naphthyridine-6-carboxylate hydrochloride (vinconate), an indolonaphthyridine derivative, on neurotransmitter receptor systems in the rat brain using quantitative receptor autoradiography. [ 3H]Quinuclidinyl benzilate (QNB), [ 3H]hemicholinium-3 (HC) and [ 3H]muscimol were used to label acetylcholine receptors, high-affinity choline uptake sites and γ-aminobutyric acid A (GABA A) receptors, respectively. [ 3H]QNB, [ 3H]HC and [ 3H]muscimol binding decreased in any brain areas of 24-month-old (aged) rats in comparison with 6-month-old (adult) animals. Chronic treatment with vinconate (10 and 30 mg/kg, i.p., once a day for 4 weeks) partly ameliorated the reduction in [ 3H]QNB, [ 3H]HC and [ 3H]muscimol biding in aged rat brains. This effect was especially noted in [ 3H]muscimol binding. The results suggest that vinconate may have beneficial effects on age-related changes in neurotransmitter receptor systems.
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