Abstract
Antimicrotubular agents such as vinblastine and colchicine have been used to assess the role of cytoplasmic microtubules in secretory processes (for review, see 1). The purpose of this study was to determine the effects of vinblastine on the structure and function of resting and pilocarpine- stimulated acinar cells of the rat exorbital lacrimal gland.Rats were divided into four groups: (a) untreated control; (b) vinblastine (4 mg/kg) treatment for 1 to 24 hours; (c) pilocarpine (20 mg/kg) treatment for 1 hour; and (d) vinblastine treatment for 1 hour, followed by pilocarpine treatment for 1 hour. Both drugs were administered via single intraperitoneal injections. The glands were fixed by perfusion and processed for electron microscopy.
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