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Abstract
BackgroundVildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is wildly used to treat type 2 diabetes mellitus (T2DM) with mono- or combination-therapy. We review two previously published open-label studies to extract insights on the long-term efficacy and safety of vildagliptin.MethodsTwo studies were conducted in Japan to assess the efficacy and safety of vildagliptin as an add-on to other oral antidiabetes drugs (OADs) for 52 weeks. These studies were performed under the similar protocol in Japanese patients with T2DM who were inadequately controlled with OAD monotherapy [excluding other dipeptidyl peptidase-4 (DPP-4) inhibitors].ResultsAddition of vildagliptin (50 mg twice daily) to other OAD monotherapy [sulfonylurea (SU), metformin, thiazolidinedione, alpha-glucosidase inhibitor and glinide] reduced glycated hemoglobin (HbA1c) levels by −0.64 %,−0.75 %,−0.92 %,−0.94 % and − 0.64 %, respectively, over 52 weeks of treatment. Overall, the incidence of hypoglycemia was low and was slightly higher in the add-on to SU treatment group compared with the other groups. The incidences of adverse events were comparable among the treatment groups, and vildagliptin was well-tolerated as add-on therapy to other OADs.ConclusionsThe evidence from the two studies indicates that vildagliptin as an add-on therapy to other OADs is a clinically reasonable option for Japanese patients with T2DM who respond inadequately to other OAD monotherapy.
Highlights
Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is wildly used to treat type 2 diabetes mellitus (T2DM) with mono- or combination-therapy
The Japanese guideline [1] and the international guidelines [2] for management of patients with type 2 diabetes mellitus (T2DM) recommend maintaining tight glycemic control to suppress aggravation and/or occurrence of vascular complications, providing that tight glycemic control can be achieved without hypoglycemia or other significant adverse effects
The present study reviewed the results of two openlabel studies [16, 17] to provide insights on the long-term efficacy and safety of vildagliptin in combination with other oral antidiabetes drugs (OADs) in Japanese patients with T2DM with inadequate glycemic control on OAD monotherapy
Summary
Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is wildly used to treat type 2 diabetes mellitus (T2DM) with mono- or combination-therapy. The Japanese guideline [1] and the international guidelines [2] for management of patients with type 2 diabetes mellitus (T2DM) recommend maintaining tight glycemic control to suppress aggravation and/or occurrence of vascular complications, providing that tight glycemic control can be achieved without hypoglycemia or other significant adverse effects. The. Japanese Diabetes Society (JDS) recommends glycated hemoglobin (HbA1c)
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