Abstract
Intravenous verapamil prolonged survival in mice challenged with intravenous Chironex fleckeri venom prepared from clarified nematocyst suspensions. Ovoid antivenom protected mice who had been challenged but only over a limited dose range. Verapamil also enhanced the beneficial effect of ovine antivenom but again was most active only over a restricted dose range. This data suggests that there may be an, as yet undefined, optimal antivenom dose for humans and that verapamil, used in combination with antivenom is an effective agent.
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