Abstract
BackgroundVentricular conduction blocks (VCBs) are associated with poor outcomes in patients with known cardiac diseases. However, the prognostic implications of VCB patterns in dilated cardiomyopathy (DCM) patients need to be evaluated. The purpose of this study was to determine all-cause mortality in patients with DCM and VCB.MethodsThis cohort study included 1119 DCM patients with a median follow-up of 34.3 (19.5–60.8) months, patients were then divided into left bundle branch block (LBBB), right bundle branch block (RBBB), intraventricular conduction delays (IVCD) and narrow QRS groups. The all-cause mortality was assessed using Kaplan-Meier survival curves and Cox regression.ResultsOf those 1119 patients, the all-cause mortality rates were highest in patients with IVCD (47.8, n = 32), intermediate in those with RBBB (32.9, n = 27) and LBBB (27.1 %, n = 60), and lowest in those with narrow QRS (19.9 %, n = 149). The all-cause mortality risk was significantly different between the VCB and narrow QRS group (log-rank χ2 = 51.564, P < 0.001). The presence of RBBB, IVCD, PASP ≥ 40 mmHg, left atrium diameter and NYHA functional class were independent predictors of all-cause mortality in DCM patients.ConclusionsOur findings indicate that RBBB and IVCD at admission,but not LBBB, were independent predictors of all-cause mortality in patients with DCM.
Highlights
Ventricular conduction blocks (VCBs) are associated with poor outcomes in patients with known cardiac diseases
There is controversy regarding the type of bundle branch block (BBB) that is associated with poorer outcomes in patients with heart failure (HF) [4,5,6,7,8]
In the present study, we evaluated the association of VCB patterns and all-cause mortality and compared the prognostic values of right BBB (RBBB), left BBB (LBBB), and intraventricular conduction delays (IVCD) in hospitalized patients with dilated cardiomyopathy (DCM)
Summary
Ventricular conduction blocks (VCBs) are associated with poor outcomes in patients with known cardiac diseases. The purpose of this study was to determine all-cause mortality in patients with DCM and VCB. The clinical spectrum is wide, and it is Patients with DCM present with an increase in the QRS duration in the presence of a ventricular conduction block (VCB) [1,2,3]. Most studies indicate that left BBB (LBBB) is an independent prognostic marker, whereas right BBB (RBBB) is a weaker marker or not associated with a worse prognosis. Two studies recently showed that RBBB but not LBBB is associated with an increased 1-year and 4-year mortality risk in hospitalized patients with HF [9, 10].
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.