EFFECTS OF VARIOUS VASODILATOR DRUGS ON CEREBRAL CIRCULATION

Abstract

1. The changes in cerebral hemodynamics and metabolism were measured by N20 method after the administration of various vasodilator drugs. 2. A decrease in CBF and an increase in CVR were observed by the administration of caffein, theophylline ethylendiamine and oxyethyl-theophylline. No changes were observed in both CBF and CVR by diethyl-amino-ethyl-theophylline and Parmanil. 3. ATP caused no effect on CBF, but a slight fall of CVR. CMRO2 increased significantly by intravenous injection of ATP together with 40% glucose solution. A decrease in CBF and an increase in CVR were observed by Lacarnol, but these changes were not statistically significant. No significant changes were seen in CBF and CVR after the intravenous administration of Kallikrein. 4. Priscol and nicotinid acie produced no changes in CBF, CVR and CMRO2. An insignificant increase in CBF and CMRO2 was seen by the administration of Vasculat, acetylcholine and amyl-nitrite. Papaverine hydrochloride is the only agent among several vasodilators used at present by which a certain increase in CBF occurs.