Abstract
Continuously stimulated rabbit atria show a decline in contractile tension during and after exposure to special hypertonic solutions. Muscles were equilibrated in Ringer-Locke solution, incubated in hypertonic glycerol or urea media, and returned to normal Ringer's solution. Certain parameters of the contractile response were measured and compared quantitatively during the incubation and removal periods. The change of the contractile force was noted following different incubation times and different incubation concentrations. Effects of different tonicities of glycerol and urea were compared. The influence of the incubation concentration and time governing the effects during incubation and removal could be shown. The differences in action between low glycerol and urea concentrations during incubation and removal probably reflect a result caused by the difference in penetration speed of the molecules. The contractile changes following the removal of glycerol are accompanied by ultrastructural changes. There is a progressive swelling and disruption of the sarcotubular system and mitochondria with increasing incubation times and concentrations.
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