Abstract
The hypothermic effect of oxotremorine, 0.5 mg/kg, i.p., in mice, at an environmental temperature of 22°C, has been found to be antagonized by atropine and a variety of antihistamines in a dose-related manner. The relative molar potency, at the ED 5 0 was atropine cyproheptadine chlorpheniramine diphenhydramine tripelennamine pyrilamine (mepyramine) chlorcyclizine; promethazine was inactive. Protection by these antihistamines could not be correlated with the relative antihistaminic or anticholinergic potencies of the compounds tested. Cyproheptadine caused a 2–3°C drop in temperature at a dosage range of 5–20 mg/kg.
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