Abstract
An evaluation of 17α-alkyl substitutions of varying length and degree of saturation indicated that steroids possessing a methyl group produced more marked effects on BSP retention in rabbits than longer alkyl sidechains. Non-17α-alkylated steroids possessing an alkyl group at positions other than C-17 were devoid of significant effects on BSP retention. Several 17α-alkylated steroids that did not alter BSP retention in rabbits were certain gD 4-3-ketosteroids with substitutions at C-16 and C-17, and certain saturated A-ring steroids.
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