Abstract
Aims: Phosphodiesterase-5-inhibitors are vasoactive drugs used in the treatment of erectile dysfunction and pulmonary hypertension. Their beneficial effects in the pulmonary vasculature are widely described, but it remained unclear, how they influence cardiac performance. In the present study we investigated the effects of the phosphodiesterase-5-inhibitor vardenafil on myocardial and vasomotor function in a rat model.
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