Abstract
Background: Tendon healing is divided into several stages. After a tendon rupture, blood will collect and clot at the injury site, which is the hemorrhagic phase in tendon healing. Normally, platelets degranulate and release large amounts of cytokines and growth factors. Giving growth factors from outside, namely by platelet-rich plasma (PRP) in previous studies, was hypothesized to enhance the tendon repair process. This study is an exploratory study to determine the potential use of platelet-rich plasma (PRP) for the healing of Achilles tendon rupture in vivo studies.
 Methods: In vivo post-test experimental study with the control group. A total of 12 rats were grouped into control and treatment. Assessment of healing of the Achilles tendon rupture was carried out by the histopathological score. Univariate and bivariate analyzes were carried out with the help of SPSS.
 Results: The control group had higher scores for structure and fiber arrangement, nucleus shape, inflammation, and neovascularization than the treatment group. Likewise with the total histological score, where the control group had a higher total histological score than the treatment group, with p <0.05.
 Conclusion: PRP administration did not have a better effect on the healing process of Achilles tendon rupture in vivo studies.
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