Abstract
The effect of undernutrition during suckling on neurochemical and behavioral parameters were investigated in adult rats. Young rats were undernourished by suckling their lactating mothers fed an 8% (by wt) protein diet. Mothers of normal rats were fed a 20% protein diet. After weaning (d 21), normal and undernourished rats were fed a 20% protein diet until 90–120 d of age, when the rats were subjected to a short shuttle avoidance session and/or killed for neurochemical analyses. During shuttle avoidance sessions, footshock escape and footshock avoidance responses were analyzed simultaneously using 0.2- or 0.8-mA footshock intensity. In addition, the effect of undernutrition during suckling on phosphoryl-serine (P-Ser) level in brain nuclear proteins and the response of this level to a shuttle avoidance session were studied. We observed that undernutrition during suckling had no effect on footshock avoidance responses and decreased the latencies of footshock escape responses using 0.2-mA footshock intensity. Undernutrition decreased the basal level of P-Ser in brain nuclear proteins and abolished the decrease of this level observed in a shuttle avoidance session in normal rats using 0.2- or 0.8-mA footshock intensity.
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