Abstract
Under similar experimental conditions, a variety of uncouplers, including newly synthesized carbonylcyanide phenylhydrazone (CCP) derivatives and new sulfhydryl compounds, have been compared as to their activities in completely releasing respiratory control in rat liver mitochondria and in increasing the specific conductance of bilayer lipid membranes (BLM) by 10-fold. The results indicate that there is no simple correlation between the relative effectiveness of the uncouplers on mitochondrial respiratory control and their effects on the conductance of BLM. It is concluded that the simple concept of uncouplers as proton conductors across the mitochondrial membrane is not an adequate general explanation of their effect on oxidative phosphorylation.
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