Abstract
Tanning refers to the practice of darkening the pigment of one's skin through exposure to natural sunlight or artificial Ultraviolet (UV) radiation. Studies have explored the molecular mechanism of tanning induced by UV radiation exposure. UV radiation triggers DNA damage in the nucleus of keratinocytes, which induces production of melanin by melanocytes. The melanin is then transported to keratinocytes and manifests as darker pigmentation. An increasing amount of data accumulate to support a role for UV exposure in the development of both melanoma and non-melanoma skin cancers. This article reviews the body of literature reporting the effects of UV exposure on melanocyte biology, skin pigmentation, and melanoma
Highlights
Tanning refers to the practice of darkening one's skin pigmentation through natural sunlight and artificial ultraviolet (UV) exposure
Studies have explored the molecular mechanism of darkening one's skin pigmentation through exposure to UV radiation, and an increasing amount of data supports the role of UV exposure in the development of both melanoma and non-melanoma skin cancers
This article reviews the body of literature reporting the effects of UV exposure on melanocyte biology, skin pigmentation, and melanoma
Summary
Elena B Hawryluk, Asli Oztan and David E Fisher3 1Dermatology Program, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA 2F.
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