Effects of Ultrasound on Reactive Crystallization and Particle Properties of an Aromatic Amine in Batch and Continuous modes

Abstract

Ultrasound has shown its benefits in the manufacturing processes of many pharmaceuticals and fine chemicals. This study focused on the reactive crystallization system of an aromatic amine and explored the potential uses of ultrasound in both batch and continuous modes. In batch experiments, we studied the effects of different sonication conditions including power, duration, and starting point on final particle properties. Under ultrasound, the crystal form and crystal morphology remained well maintained. The results of particle size and size distribution suggested that ultrasound reduced the mean sizes by improving the nucleation process and breaking up large particles. Additionally, the presence of ultrasound in continuous experiments was capable of inducing nucleation and the crystal products collected had a suitable distribution. Integrating ultrasound into the beginning of the continuous crystallization process can be an alternative to the seeding technique. The increasing sonication power did not reduce the induction time substantially. This indicated that a rational sonication condition should balance the overall process efficiency and energy consumption. The findings from batch and continuous experiments indicate that ultrasound could intensify industrial crystallization of the aromatic amine. Incorporating energy-efficient ultrasound with the continuous process will potentially lead to increased production efficiency and a well-controlled product quality.