Abstract
Ultimobranchialectomy (UBX) was performed on day-old chickens in an attempt to study the effects of calcitonin deficiency upon serum calcium and phosphorus and bone mineral and matrix metabolism. All studies were initiated 5 weeks after UBX. UBX was associated with no abnormalities of base-line serum calcium or alkaline phosphatase but the UBX chicks receiving a normal calcium diet had lower serum P than control groups. Parathyroid extract (PTE) treatment caused hypocalcemia 8 hr after injection in the control group receiving normal Ca diet, whereas the UBX group returned to base-line serum Ca. PTE treatment of normal chicks receiving the low Ca diet caused an initial hypocalcemic response, whereas UBX chicks exhibited hypercalcemia. The serum P of intact chicks on the normal diet increased after treatment with PTE, whereas the UBX chicks had decreased serum P values. Quantitative microradiographic analysis of bone formation, resorption and total bone surface area revealed no significant differences betwe...
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