Abstract
Aim We sought to evaluate the effects of ulinastatin on postoperative systemic inflammatory responses of recipients of rat small bowel transplantations (SBT). Methods Twenty-four recipients of rat heterotopic SBT were randomly divided into a control group and a treated group. Ulinastatin (50,000 U/kg −1/d −1) was injected intravenously 30 minutes before graft revascularization. Measured variables included plasma concentrations of tumor necrosis factor (TNF), interleukin (IL)-6, and C-reactive protein (CRP) on postoperative days 1 and 3. Results Administration of ulinastatin attenuated the postoperative increases in plasma concentrations of TNF, IL-6, and CRP. Conclusion Ulinastatin attenuated the postoperative systemic inflammatory response of rat recipients of SBT.
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