Abstract
BackgroundAlpha-mangostin has potential as a chemopreventive agent but there is little information on its toxicological profile and developmental toxicity.ObjectiveWe evaluated the effects of α-mangostin on embryonic development and hepatogenesis in zebrafish.ResultExposure of embryos to 0.25–4 μM α-mangostin from 4–120 h post-fertilization (hpf) caused mortality of embryos with LC50 1.48 ± 0.29 μM. The compound also caused deformities, including head malformation, pericardial oedema, absence of swim bladder, yolk oedema, and bent tail. Exposure of zebrafish embryos to α-mangostin during early hepatogenesis (16–72 hpf) decreased the transcript expression levels of liver fatty acid-binding protein 10a (Fabp10a), but increased gene markers of inflammation, oxidative stress, and apoptosis. In Fabp10a:DsRed transgenic zebrafish, the intensity and the area of fluorescence in the liver of the treated group were decreased (non-significantly) relative to controls.ConclusionThese effects were more marked during early hepatogenesis (16–72 hpf) than during post-hepatogenesis (72–120 hpf).
Highlights
Claims for human health improvement have popularized mangosteen-based drinks
Relatively few studies have evaluated the toxicological profile of α-mangostin, and most of these have focused on rodent models (Her et al 2003)
This study evaluated the toxicological effects of α-mangostin on embryonic development and hepatogenesis in zebrafish
Summary
Claims for human health improvement have popularized mangosteen-based drinks. The mangosteen (Garcinia mangostana), a tropical fruit that mainly occurs in Southeast Asia, is used as a traditional medicine in the treatment of abdominal pain, infected wounds, and dysentery (PedrazaChaverri et al 2008). Alpha-mangostin is one of the active compounds obtained from mangosteens (Jindarat 2014). This compound has been investigated for biological properties, including antioxidant, antibacterial, anti-inflammatory, and anticancer activities (Pimtong et al 2014; Wang et al 2017; Chen et al 2018). Objective We evaluated the effects of α-mangostin on embryonic development and hepatogenesis in zebrafish. Exposure of zebrafish embryos to α-mangostin during early hepatogenesis (16–72 hpf) decreased the transcript expression levels of liver fatty acid-binding protein 10a (Fabp10a), but increased gene markers of inflammation, oxidative stress, and apoptosis. Conclusion These effects were more marked during early hepatogenesis (16–72 hpf) than during post-hepatogenesis (72–120 hpf)
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