Abstract
By means of suitable trochars and rubber tubing, one may observe intrapleural pressures from both sides of the chest of normal unanesthetized dogs. The tubing may be branched so that both manometric and kymographic records may be obtained for intrapleural pressure changes from each side of the chest. With such an arrangement we have noted the effects on intrapleural pressure of the administration of (1) epinephrin, a typical stimulant of the thoraco-lumbar autonomics and (2) atropine, a drug acting by peripheral paralysis of the cranio-sacral autonomics. Both drugs cause bronchodilatation.Examples of approximate intrapleural pressure changes in dogs following the administration of these drugs are offered in the tables. The mean pressure, which is given in a separate column, is the average of the intrapleural pressure at inspiration and expiration. It is difficult to obtain satisfactory manometric readings with a rapidly moving column of water and, therefore, the kymograph tracings probably present a bette...
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