Abstract
Purpose: Osteoarthritis (OA) is the fourth leading cause of disability worldwide, and it is estimated that it affects more than 40 million people across Europe. Obesity is a major risk factor for OA, which is attributed both to mechanic (high body mass) and metabolic (low-grade systemic inflammation caused by obesity-associated metabolic syndrome) factors. High-fat (HF) and high-fat/high-sucrose (HFS) diets are widely used to investigate the relationship between obesity and OA in animal models, but different diet compositions might have a different effect on the development of OA.
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