Abstract
Background. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconclusive or even controversial. A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk. Methods. A comprehensive literature search was performed in multiple internet-based electronic databases. Data from 12 eligible studies were extracted to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI). Results. C allele of rs2910164 is associated with reduced gastric cancer risk in heterozygote model and dominant model whereas rs11614913 indicates no significant association. Subgroup analysis demonstrates that C allele of rs2910164 and rs11614913 may decrease susceptibility to diffuse type gastric cancer in dominant model and recessive model, respectively, while rs11614913 increased intestinal type gastric cancer in dominant model. Conclusion. SNPs rs2910164 and rs11614913 might have effect on gastric cancer risk in certain genetic models and specific types of cancer. Further well-designed studies should be considered to validate the potential effect.
Highlights
IntroductionIt is estimated that 989,600 new gastric cancer cases were diagnosed in 2008 and caused 738,000 deaths in a single year
Gastric cancer is among the leading causes of cancer-related death worldwide
Despite decreasing incidence of gastric cancer in developed countries, gastric cancer remains a major health problem globally, especially in Eastern Asia, Eastern Europe, and South America, which may be attributed to particular dietary pattern, high prevalence of Helicobacter pylori infection, and limited availability to proper food storage [2,3,4]
Summary
It is estimated that 989,600 new gastric cancer cases were diagnosed in 2008 and caused 738,000 deaths in a single year. Epidemiological studies have shed light on risk factors of gastric cancer including lifestyle factors, environmental carcinogens, and, importantly, Helicobacter pylori infection [5, 6]. These risk factors cannot fully explain the development of gastric cancer since only a minority of exposed population developed gastric cancer, indicating possible interplay between risk factors and personal background including genetic susceptibility [7]. A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk. Further well-designed studies should be considered to validate the potential effect
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