Abstract
Objective Solid dispersions of daidzein (DZ) were prepared using tween-80 as the surfactant to improve itsdissolution and solubility. Methods Using tween-80 as the surfactant and polyethylene glycol (PEG)-10000 as thecarrier, solid dispersions of DZ were prepared by solvent method. Infrared spectroscopy (IR) and X-ray diffractionspectroscopy were applied to determine the status of DZ in carriers. Results When appropriate amount of Tween-80was added into the solid dispersion, the dissolution of DZ could be improved obviously. The data of IR showed theabsence of well-defined drug-polymer interactions. The data of X-ray diffraction showed that the drug might exist inthe form of amorphism or molecule in solid dispersions. Conclusion Appropriate amount of Tween-80 couldincrease the dissolution rate of DZ.
Highlights
Daidzein, extracted from Traditional Chinese Medicine (Guo, 1996, PP. 146-148), was synthesized in 1972 by China
DZ solid dispersion was prepared by solvent method, using polyethylene glycol (PEG) as carrier, and surfactant Tween-80 was added during the preparation process
The dissolution rate of DZ solid dispersion with or without Tween-80 increased with the decreasing ratio of drug to PEG, and the drug dissolution rates were classified in this order: DZ
Summary
Daidzein, extracted from Traditional Chinese Medicine (Guo, 1996, PP. 146-148), was synthesized in 1972 by China. DZ could expand coronary artery, reduce myocardial oxygen consumption, increase the coronary and cerebral blood flow, and ameliorate the symptoms of patients with hypertension such as headache, dizziness, nuchal rigid pain and so on obviously. It could significantly alleviate angina pectoris, possessed anti-arrhythmia and antioxidant properties, enhanced the body’s immune system, and had pharmacological effects of lowering blood sugar. In clinical practice, it was principally applied as target medicine for angina pectoris, hypertension and cardiovascular disease Effects of Tween-80 on the dissolution of DZ in PEG solid dispersion were investigated
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