Abstract
In rats carrying Walker carcinomas transplanted subcutaneously, splenomegaly (a 2- to 5-fold increase in spleen weight) is associated with striking increases (5- to 30-fold/g spleen) in the concentration of thymidine kinase. This may reflect active erythropoiesis since thymidine kinase is also at unusually high levels in the spleen of 4- to 5-day-old rats and in adult rats after phenylhydrazine treatment. Cortisone treatment did not affect the thymidine kinase concentration of host spleen or normal bone marrow, but in thymus it caused a drastic fall. The most prominent changes among five other enzymes studied were the increase of hexokinase and the decrease of glutamyltransferase in the spleen, and also in bone marrow and liver, of tumor-bearing rats.
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