Abstract

Effects of endogenous and exogenous TSH on rabbit thyroid cell membrane properties were studied. Both propylthiouracil (PTU) pretreatment and acute cold stress produced a fall in transmembrane potentials. PTU pretreated rabbit follicles had higher capacitances and lower resistances across their walls than follicles from control rabbits. This can be explained on the basis of increased membrane area. PTU pretreated animals also had a lower luminal electrical potential. In perfused glands in vitro, the addition of TSH to the perfusate produced a rapid fall in resistance and an increase in capacitance across the follicular wall. These changes are attributed to an increase in membrane area and to a fall in specific membrane resistance. (Endocrinology 86: 1154, 1970)

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